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    ZTS
    Earnings call· Jun 2025(Q2 FY25)

    Zoetis Q2 FY25 earnings call ZTS

    Aug 5, 2025 Source

    Executive summary

    Zoetis Q2 FY25 — Strong Broad-Based Growth & Raised Full-Year Guidance

    Zoetis delivered strong broad-based growth in Q2 FY25, driven by its diversified portfolio and innovation engine, leading to a raise in full-year guidance. While Librela adoption faced headwinds, the company is investing in education and studies to accelerate its trajectory. The company remains confident in its ability to adapt to competitive and macroeconomic challenges, including tariffs, through disciplined execution and cost management.

    Highlights

    5
    • Organic operational revenue grew 8% in Q2 FY25, driven by 4% price and 4% volume.

    • Adjusted net income grew 10% on an organic operational basis in Q2 FY25.

    • International segment organic operational revenue grew 9%, with Livestock up 10% and Companion Animal up 8%.

    • Simparica franchise grew 17% operationally, with Simparica Trio up 20% operationally, demonstrating continued market leadership.

    • Key Dermatology franchise grew 11% operationally, fueled by strong international uptake and compliance.

    Concerns

    4
    • Librela declined 7% operationally globally and 16% in the U.S. on $45 million in revenue, lagging expectations due to adoption headwinds and perceived safety concerns.

    • U.S. Livestock declined 2% organically due to timing of ceftiofur supply.

    • Higher manufacturing costs partially offset margin benefits, in line with expectations, as the company works through inventory valued at prior year standards.

    • Increased impact of tariffs is expected, partially offsetting improved margin expectations.

    Guidance & targets

    10
    CategoryTargetConfidence
    Full-year 2025 Organic Operational Revenue Growth
    6.5% to 8%
    high materiality
    High
    Full-year 2025 Organic Operational Adjusted Net Income Growth
    5.5% to 7.5%
    high materiality
    High
    Full-year 2025 Revenue
    $9.45 billion to $9.6 billion
    high materiality
    High
    Full-year 2025 Adjusted Net Income
    $2.825 billion to $2.875 billion
    high materiality
    High
    Full-year 2025 Adjusted Diluted EPS
    $6.30 to $6.40
    high materiality
    High
    Full-year 2025 Reported Diluted EPS
    $5.90 to $6.00
    medium materiality
    High
    Key Franchises (Derm, Simparica, OA Pain) Combined Growth
    double digits
    medium materiality
    High
    Triple Combination Market Expansion
    double by end of 2028
    medium materiality
    High
    Major Market Approval
    every year for the next few years
    high materiality
    High
    Long-acting OA Pain Approval
    approval in a major market this year
    high materiality
    High

    Segment performance

    6
    SegmentRevenueYoYQoQMargin
    U.S. Total
    Revenue growth driven by Companion Animal, partially offset by Livestock decline.
    Organic operational growth: 7%
    4% reported
    U.S. Companion Animal
    Growth driven by Simparica and Key Dermatology, partially offset by OA pain mAbs decline. Benefited from strong alternative channel sales.
    Simparica franchise revenue: $329 millionSimparica franchise growth: 18%Key Dermatology sales: $307 millionKey Dermatology growth: 9%OA Pain mAbs sales: $62 millionOA Pain mAbs growth: -12%Librela sales: $45 millionLibrela growth: -16%Solensia sales: $17 millionSolensia growth: -3%
    9% organic operational
    U.S. Livestock
    Primarily driven by timing of supply of ceftiofur.
    -2% organic operational
    International Total
    Strong organic operational growth across Companion Animal and Livestock.
    Organic operational growth: 9%
    3% reported
    International Companion Animal
    Growth driven by Key Dermatology and Simparica franchises. Librela impacted by social media headwinds in English-speaking markets.
    Key Dermatology revenue: $153 millionKey Dermatology growth: 15% operationalSimparica franchise sales: $119 millionSimparica franchise growth: 16% operationalSimparica Trio sales: $55 millionSimparica Trio growth: 22% operationalSimparica sales: $64 millionSimparica growth: 12% operationalOA Pain mAbs combined revenue: $83 millionOA Pain mAbs growth: 4% operationalLibrela sales: $64 millionLibrela growth: 1% operationalSolensia sales: $19 millionSolensia growth: 17% operational
    8% operational
    International Livestock
    Growth across all core species, driven by swine (China tailwinds), vaccines in Latin America, Fish portfolio (Norway and Chile), and Poultry (Middle East and Asia). Cattle benefited from price contributions.
    10% organic operational

    Operational metrics

    13
    Organic Operational Revenue Growth
    8%
    Q2 FY25

    Excludes impact of foreign exchange and MFA divestiture.

    Adjusted Net Income Growth
    10%
    Q2 FY25

    On an organic operational basis.

    Adjusted Diluted EPS Growth
    13%
    Q2 FY25

    On an organic operational basis.

    Adjusted Gross Margin
    73.7%up 200 bps reported
    Q2 FY25

    Higher margins due to MFA divestiture and price, partially offset by manufacturing costs.

    Adjusted Operating Expenses Growth
    5%
    Q2 FY25

    On an operational basis.

    SG&A Growth
    6%
    Q2 FY25

    On an operational basis.

    R&D Growth
    1%
    Q2 FY25

    On an operational basis.

    Alternative Channel Sales
    22%growing mid-20% range
    Q2 FY25

    Represents percentage of total U.S. Companion Animal sales, driving better compliance and stickiness.

    Triple Combination Share in Vet Practices
    45%up from 30%
    Q2 FY25

    Reflects expansion of the market segment.

    Untreated/Undertreated Dogs with OA
    27 milliononly 9 million currently treated
    Current

    Highlights significant market opportunity for OA pain solutions.

    Untreated/Undertreated Dogs with Derm
    20 million
    Current

    Represents meaningful runway for Key Dermatology franchise.

    Puppy Share for Triple Combinations
    60%
    Current

    Percentage of puppies immediately starting on triple combination parasiticides.

    Contract Manufacturing (Human Health)
    Q2 FY25

    Relatively small number for the company, saw a bit of pickup in the quarter.

    Industry KPIs

    10
    MetricValueDetails
    Prescription volume60%%
    EPS revenue guidanceRevenue: $9.45B-$9.6B; Adj. Net Income: $2.825B-$2.875B; Adj. Diluted EPS: $6.30-$6.40USD
    Pricing policy impactSlightly higher
    Product franchise net sales$448 millionUSD
    Pipeline clinical milestonesMajor market approval every year
    Regulatory approvals filingsConditional license
    Therapeutic drug market share45%%
    Price volume mix decomposition4% price, 4% volume%
    Geographic regional revenue growthU.S.: 7% organic operational; International: 9% organic operational%
    Clinical trial efficacy safety dataOver 75%%

    Risks & headwinds

    6
    Librela adoption headwindsQ2 FY25, ongoing

    Librela declined 7% operationally globally; 16% in U.S. on $45 million sales

    Mitigation: Intensified medical education for vets, partnering with key opinion leaders, third-party Phase IV studies (reading out Q4 FY25 into FY26), engaging directly with pet owners to build awareness and demand.

    Competitive pressures in key franchisesOngoing, particularly H2 FY25 for Derm

    Simparica Trio has not experienced year-over-year patient share loss since competition launched almost 2 years ago; Key Dermatology minimal patient share impact

    Mitigation: Leveraging first-mover advantage, strong commercial relationships, alternative channel strategy, differentiated product offerings (Apoquel Chew, Cytopoint), market expansion efforts, disciplined promotional activity.

    Higher manufacturing costsQ2 FY25, improving in H2 FY25

    Partially offset margin benefits

    Mitigation: Working through inventory valued at prior year standards; expected to improve in the second half of the year.

    Tariff impactFY25

    Slightly higher than May guidance estimate; increased impact partially offsets improved margin expectations

    Mitigation: Embedded in full-year guidance; leveraging scale, diversification, robust supply chain, and U.S. manufacturing footprint; advocating against Section 232 application to Animal Health.

    Supply timing for U.S. Livestock productsQ2 FY25

    U.S. Livestock declined 2% organically

    Mitigation: Impact primarily driven by timing of supply of ceftiofur, expected to normalize.

    Social media headwinds for LibrelaQ2 FY25, ongoing

    Impact to new patient starts, particularly in English-speaking markets

    Mitigation: Echoing U.S. efforts internationally to address concerns, providing greater third-party data to underscore clinical difference.

    What to watch in Q3 FY25

    5

    Librela U.S. Growth Trajectory

    2026 benefit, with Q4 FY25 study readouts
    Current-16% in Q2 FY25
    TargetReturn to sustained growth

    Why it matters

    Librela is a breakthrough innovation with significant long-term potential, and its adoption rate is critical for future growth.

    These efforts will help our return to sustained growth and accelerate our trajectory. We remain confident in Librela long term.

    Q&A highlights

    6

    How has the go-to-market strategy changed with increased competition in Simparica Trio and Key Derm, especially regarding alternative channels? When can Librela return to growth given the ongoing education and studies?

    Zoetis has not changed its go-to-market strategy for Trio/Derm, maintaining discipline and leveraging alternative channels for compliance. Trio has not lost patient share despite competition, and the triple combination market is expected to double by 2028. For Librela, the focus is on medical education and third-party studies (reading out Q4 FY25 into FY26) to address perceived safety concerns and accelerate adoption, with long-term confidence remaining.

    We expect triple combinations to double by the end of 2028. So that gives you a pretty strong trajectory, which we are seeing play out both, again, last year and this year.

    asked by Michael Ryskin · answered by Wetteny Joseph

    2 min read6 chapters

    Detailed Narrative

    01

    Strong Q2 Performance and Full-Year Outlook

    Zoetis delivered robust Q2 FY25 results with 8% organic operational revenue growth and 10% adjusted net income growth on an organic operational basis. This performance was broad-based across markets, species, franchises, and channels, driven by both price and volume. The strong first-half results, with 9% organic operational revenue growth, led the company to raise its full-year guidance for both revenue and adjusted net income, despite anticipated competitive headwinds in the second half.

    02

    Companion Animal Franchise Momentum

    The Companion Animal portfolio grew 8% operationally, with key franchises like Simparica and Key Dermatology showing significant strength. The Simparica franchise grew 17% operationally, with Simparica Trio up 20%, maintaining market leadership despite competition by leveraging first-mover advantage and alternative channels. The Key Dermatology franchise grew 11% operationally, demonstrating durability through its diverse offerings (Apoquel, Cytopoint) and continued market expansion efforts, particularly internationally.

    03

    Librela Adoption Challenges and Mitigation

    Librela, the OA pain monoclonal antibody, experienced a 7% operational decline globally and 16% in the U.S., falling short of expectations. Headwinds include perceived safety concerns among vets and pet owners, exacerbated by social media in English-speaking markets. Zoetis is actively addressing this through intensified medical education, partnerships with key opinion leaders, and investing in third-party Phase IV studies expected to read out from Q4 FY25 into FY26 to provide further clinical validation and support adoption.

    04

    Livestock Segment Outperformance

    The Livestock business continued its strong performance, growing 6% organically and operationally in Q2, exceeding low single-digit market growth projections. This marks the fifth consecutive quarter of above 5% organic operational growth, driven by double-digit gains internationally, particularly in swine (benefiting from China tailwinds), vaccines in Latin America, and strong fish and poultry portfolios. The segment's momentum is expected to continue through the year, reinforced by rising U.S. protein consumption.

    05

    Pipeline and Future Innovation

    Zoetis highlighted its robust pipeline, expecting a major market approval every year for the next few years. This includes a conditional license for an Avian Influenza Vaccine for lactating dairy cattle in the U.S. and anticipated approval for a new long-acting OA Pain monoclonal antibody (3-month duration) for dogs and cats this year. The company is also developing long-acting Cytopoint and exploring new markets in renal, oncology, and cardiology, which represent significant unmet needs and multi-billion dollar opportunities.

    06

    Tariff Environment and Resilience

    The company acknowledged the dynamic tariff environment, noting that the impact of currently enacted and announced tariffs is slightly higher than previously estimated. However, Zoetis expressed confidence in its ability to absorb the incremental impact and manage costs due to its resilient business model, diversified supply chain, and significant U.S. manufacturing footprint (60% globally, 75% of U.S. sales manufactured in the U.S.). The company is actively advocating against the application of Section 232 tariffs to Animal Health.

    AI-generated summary of the company’s earnings call. Not investment advice.